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Pragma
- Description
- Angiotensin-Converting Enzyme I inhibitor and aldosterone antagonist.
- For use in dogs.
- Bi-grooved palatable tablets.
- Formula
- Each 500 mg tablet contains:
Benazepril Hydrochloride …… 2.5 mg
Spironolactone…………………….10 mg
Excipients q.s. ………….. 500 mg - Each 1000 mg tablet contains:
Benazepril Hydrochloride ………. 5 mg
Spironolactone ……………. 20 mg
Excipients q.s.. ………… 1000 mg - Each 2000 mg tablet contains
Benazepril Hydrochloride…….. 10 mg
Spironolactone ……………. 40 mg
Excipients q.s. ………… 2000 mg- Angiotensin-Converting Enzyme I inhibitor and aldosterone antagonist.
- For use in dogs.
- Bi-grooved palatable tablets.
- Each 500 mg tablet contains:
- Indications
Angiotensin-Converting Enzyme I inhibitor and aldosterone antagonist.
It is prescribed in dogs for the treatment of congestive heart failure (CHF) caused by atrioventricular valve insufficiency (mitral and/or tricuspid) or by dilated cardiomyopathy.
The association of spironolactone and benazepril is beneficial as both act on the renin-angiotensin-aldosterone system (RAAS) but at different levels along the cascade. Benazepril, by preventing the formation of Angiotensin-Converting Enzyme, produces vasodilation and inhibits aldosterone secretion. Spironolactone, as an antagonist of aldosterone, blocks aldosterone escape and, thus, prevents the appearance of myocardial fibrosis and ventricular arrhythmias.
- Package
For 5 kg of body weight: box with 20 palatable tablets of 500 mg.
For 10 kg of body weight: box with 20 palatable tablets of 1000 mg.
For 20 kg of body weight: box 20 palatable tablets of 2000 mg.
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